We observed the effect of the administration of vitamin A, C and E with h-naphthoflavone and piperonyl butoxide on cytochrome P-450 level and lipid peroxidation in rats liver.
The level of hepatic cytochrome P -450 decreased after vitamin A, C and E was adminstration. In contrast, p--naphthoflavone, when administered with vitamin A ,C and E, the increase of cytochrome P-450 was prevented.
Lipid peroxidation was ´decreased aftei vitamin A, C, and E was administer-ed. Moreover when #-naphthoflavone was administered together with vitamin A, C and E lipid peroxidation was not increased. When piperonyl but dde was administered together with vitamin AC and E, both cytochrome P-450 and lipid peroxidation were decreased.
These results indicate that vitamin antioxidants can prevent lipid peroxidation by a cytochrome P-450 dependent terminal oxidase system in rat liver micro-comes.
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